硕士生导师

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李瑞

作者:食品科技学院 审核人:食品科技学院 发布日期:2022-03-22 浏览次数:


98CB

博士 副研究员 硕士生导师

所在团队:海洋功能因子与营养健康

研究方向:海洋生物制品研发与应用;

                 海洋生物产品及其副产物、亚热带农产品综合加工与利用

电子邮件(E-mail):lirui@gdou.edu.cn

电话(Tel)137 0755 2195

简历

2019/12 – 至今,广东海洋大学食品科技学院食品质量与安全系,副研究员

2012/08 – 2016/12,澳大利亚迪肯大学生命与环境科学学院,博士

2014/01 – 2019/12,中国热带农业科学院椰子研究所,副研究员

2006/07 – 2013/12,中国热带农业科学院椰子研究所,研究实习员/助理研究员

2003/09 – 2006/06,江南大学,食品科学,硕士

1999/09 – 2003/06,河南农业大学,食品科学与工程,本科


研究内容

1. 海洋生物制品研发与应用

以海洋多糖、蛋白等为主要原料,制备多糖/蛋白质基水凝胶、纳米粒子、纳米乳液、Pickering乳液等,并研究其作为可降解膜、递送体系等的应用。

2. 海洋生物产品及其副产物、亚热带农产品综合加工与利用

以海洋生物产品(藻类、鱼类、虾类、贝类等)及其副产物,以及海红米、椰子、菠萝等亚热带农产品为对象,开展相关保鲜、综合加工利用新技术、新产品研发及副产物高值化利用研究。


主要承担项目及成果

承担项目

1. 国家自然科学基金面上项目,基于酶法富集ω-3脂肪酸复合凝聚构建高致密结构微胶囊的稳态化机制,3217225257万,2022-012025-12,参与。

2. 农业部功能食品重点实验室开放课题,基于肠-胰岛轴的岩藻多糖降血糖作用机制,2021075万元,2021-08-2023-07,主持。

3. 广东省教育厅广东省普通高校特色创新项目,基于岩藻多糖的自组装多功能纳米粒子口服胰岛素载体的构建及性质评价,2020KTSCX05110万元,2020-09 2022-08,主持。

4. 广东省科学技术厅广东省自然科学基金面上项目,基于糖肽分子自组装构建复合纳米水凝胶及其机械性能增强机理研究,2021A151501086810万元,2021-012023-12,主持。

5. 广东省科技厅广东科技计划“海外名师”项目,纳米材料控释体系的构建及海洋生物制品发展方向探讨,2020A14140100692万元,2020-092021-08,主持。

6. 广东海洋大学大学生创新训练计划项目,基于改性壳聚糖多功能食品包装膜的制备及应用,S202305660711万元,2023-062024-05

7. 广东海洋大学大学生创新训练计划项目,马尾藻岩藻多糖及其纳米粒子的免疫调节作用,S2022105660161万元2022-062023-05

8. 广东海洋大学大学生创新训练计划项目,分子量及硫酸基含量对岩藻多糖体外降血糖活性的影响,S202010566022, 1万元,2020-062022-06

9. 广东海洋大学科研启动费资助项目,岩藻多糖/鱼精蛋白纳米水凝胶口服胰岛素载体的构建及性质评价,2021.01-2024.1280万元,2021-012024-12,主持。

10. 海南省重点研发计划社会发展方向项目,高档天然椰子油旅游产品的开发,2010SF00610万,2010-072012-07,参与。

11. 国家自然科学基金地区基金,微量山梨醇三油酸酯对棕榈油结晶动力学及物理特征的影响,3116032550万,2012-012015-12,参与。

代表性论文

1. Min-Rui Tai, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong*, Aaqil Rifai, David. R. Nisbet, Colin J. Barrow, Richard J. Williams, Rui Li**. Biomimetic Triumvirate Nanogel Complexes via Peptide-Polysaccharide-Polyphenol Self-Assembly. International Journal of Biological Macromolecules, 2023, 251, 126323.

2. Rui Li, Min-Rui Tai, Yue-Rong Wu, Qing-Ling Zhou, Qiu-Yu Xia*, Sai-Yi Zhong*, Qi Yi, Colin J. Barrow, Richard J. Williams. Controlling the supramolecular ordering of fish gelatin via simultaneous assembly with fucoidan resulting in nanostructural modification and enhanced rheological performance. LWT-Food Science and Technology, 2023, 184: 115078.

3. Rui Li, Qing-Ling Zhou, Rui-Yu Yang, Shu-Tong Chen, Rui Ding, Xiao-Fei Liu, Lian-Xiang Luo, Qiu-Yu Xia*, Sai-Yi Zhong*, Yi Qi, Richard J. Williams.Determining the potent immunostimulation potential arising from the heteropolysaccharide structure of a novel fucoidan, derived from Sargassum Zhangii. Food Chemistry: X, 2023, 18(30): 100712.

4. Rui Li, Qing-Ling Zhou, Shu-Tong Chen, Min-Rui Tai, Hong-Ying Cai, Rui Ding, Xiao-Fei Liu, Jian-Ping Chen, Lian-Xiang Luo, Sai-Yi Zhong*. Chemical characterization and immunomodulatory activity of fucoidan from Sargassum hemiphyllum. Marine Drugs, 2023, 21(1): 18.

5. Rui Li, Qing-Ling Zhou, Min-Rui Tai, Kathryn Ashton-Mourney, Mathew I. Harty, Aaqil Rifai, Clare L. Parish, David R. Nisbet, Sai-Yi Zhong*, Richard J. Williams*. Simple complexity: Incorporating bioinspired delivery machinery within self-assembled peptide biogels. Gels, 2023, 9: 199.

6. 陈舒桐,周庆玲,杨睿宇,王潇潇,丁睿,李瑞*,罗连响,钟赛意. 两种马尾藻岩藻多糖的理化性质、结构表征及其增强免疫和降血糖活性. 食品科学2023, https://kns.cnki.net/kcms/detail/11.2206.ts.20230328.1433.018.html.

7. 蔡泓滢,太敏瑞,李瑞*,宋兵兵,陈建平,刘晓菲,钟赛意. 以天然多糖为基质构建口服蛋白质纳米粒子的研究进展. 食品与发酵工业, 2023, 49(15): 336-343.

8. Fei Song, Yannan Li, Bo Wang, Xiaojun Shen, Hui Wang, Rui Li*, Qiuyu Xia*. Effect of drying method and wall material composition on the characteristics of camellia seed oil microcapsule powder. Journal of the American Oil Chemists' Society, 2022, 99: 353– 364.

9. 太敏瑞,蔡泓滢,李瑞*,贾学静,刘晓菲,吉宏武,钟赛意. 不同褐藻来源岩藻多糖理化性质及其免疫调节作用. 广东海洋大学学报, 2022, 3: 62-71.

10. 太敏瑞,蔡泓滢,李瑞*,陈建平,贾学静,宋兵兵,刘晓菲,唐振冬,吉宏武,钟赛意. 多糖-蛋白质复合水凝胶研究进展. 食品与发酵工业, 2022, 48(3): 291-297.

11. 陈舒桐,俞珵,李瑞*,钟赛意. 岩藻多糖的提取、化学改性、降血糖活性及机理研究进展. 天然产物研究与开发, 2022, 34: 153-163.

12. 赖双定,龙宇,陈逸君,李瑞*,钟赛意,周鸿凯. 海水稻营养功能成分与加工利用研究进展. 粮食与油脂, 2022, 35(6): 13-15+35.

13. 李瑞, 宋晨也, 唐敏敏, 张建国, 宋菲, 夏秋瑜*. 冷冻离心法初榨椰子油的理化分析及其对猪皮抗氧化活性的影响. 中国粮油学报, 2020, 35(03):75-83.

14. 宋晨也, 蓝良妹, 唐敏敏, 宋菲, 李瑞, 赵松林, 夏秋瑜*. 牛油果椰油的湿法制备及其品质特性分析. 中国油脂, 2020, 045(004): 4-8.

15. Qiuyu Xia, Taiwo O. Akanbi, Rui Li, Bo Wang, Wenrong Yang, Colin J. Barrow*. Lipase-catalysed synthesis of palm oil-omega-3 structured lipids. Food & Function, 2019, 10: 3142-3149.(封面文章)

16. Qiuyu Xia, Taiwo O. Akanbi, Bo Wang, Rui Li, Wenrong Yang, Colin J. Barrow*. Investigating the Mechanism for the Enhanced Oxidation Stability of Microencapsulated Omega-3 Concentrates. Marine Drugs, 2019, 17(3):143.

17. San Seint Aye*, Rui Li*, Mitchell Boyd-Moss, Ben Long, Sivapryia Pavuluri, Kiara Brugemann, Yi Wang, Colin Barrow, David Nisbet, Richard Williams. Scaffolds formed via the non-equilibrium supramolecular assembly of the synergistic ECM peptides RGD and PHSRN demonstrates improved cell attachment in 3D cell culture. Polymers, 2018, 10(7), 690-702.

18. Rui Li, Natasha L. McRae, Daniel R. McCulloch, Mitchell Boyd-Moss, Colin J. Barrow, David R. Nisbet, Nicole Stupka, Richard J. Williams. Large and small assembly: combining functional macromolecules with small peptides to control the morphology of skeletal muscle progenitor cells. Biomacromolecules, 2018, 19, 825-837.

19. Rui Li, Mitchell Boyd-Moss, Benjamin Long, Anne Martel, Andrew Parnell, Steven Parnell, Andrew J.C. Dennison, Colin J. Barrow, David R. Nisbet, Richard J. Williams. Facile control over supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polyelectrolyte polysaccharide. Scientific Reports, 2017, 7, 1-8.

20. Qiuyu Xia, Bo Wang, Taiwo Akanbi, Rui Li, Wenrong Yang, Benu Adhikari, Colin J Barrow. Microencapsulation of lipase produced omega-3 concentrates resulted in complex coacervates with unexpectedly high oxidative stability, Journal of Functional Foods, 2017, 35, 499-506.

21. Minmin Tang, Qiuyu Xia, Brendan J. Holland, Hui Wang, Yufeng Zhang, Rui Li*, Hongxing Cao. Effects of different pretreatments to fresh fruit on chemical and thermal characteristics of crude palm oil, Journal of Food Science, 2017, 82(12), 2857-2863.

22. 唐敏敏, 李瑞, 赵松林, 张玉锋, 夏秋瑜*. 椰子种皮对湿法工艺制备的天然椰子油产品品质的影响. 中国粮油学报, 2017, 32(10)90-94.

23. Conor C. Horgan, Alexandra L. Rodriguez, Rui Li, Kiara F. Bruggeman, Nicole Stupka, Jared K. Raynes, Li Day, John W. White, Richard J. Williams, David R. Nisbet. Characterisation of minimalist co-assembled fluorenylmethyloxycarbonyl self-assembling peptide systems for presentation of multiple bioactive peptides. Acta Biomaterialia, 2016, 38, 11-22.

24. Rui Li, Sivapriya Pavuluri, Kiara F. Bruggeman, Benjamin M. Long, Andrew J. Parnell, Anne Martel, Steven R. Parnel, Frederick M. Pfeffer, Andrew J.C. Dennison, Kevin R. Nicholas, Colin J. Barrow, David R. Nisbet and Richard J. Williams. Coassembled bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12(5), 1397-1407.

25. Alexandra L. Rodriguez, Ting-Yi Wang, Kiara F. Bruggeman, Rui Li, Richard J. Williams, Clare L. Parish, and David R. Nisbet. Tailoring minimalist self-assembling peptides for localised viral vector gene delivery. Nano Research, 2016, Nano Research, 2016, 9(3): 674-684.

26. Rui Li, Conor Horgan, Benjamin Long, Alexandra L. Rodriguez, Colin J. Barrow, David R. Nisbet, Richard J. Williams. Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control of ionic strength and rate of pH change. RSC Advances, 2015, 5, 301-307.

27. Shane M. Hickey, Shani K. Tripcony, Rui Li, Richard J. Williams, Frederick M. Pfeffer. Organogelators based on the norbornane scaffold. Supramolecular Chemistry, 2015, 27 (5-6), 425-435.

28. Vengama N. Modepalli, Alexandra L. Rodriguez, Rui Li, Sivapriya Pavuluri, Kevin R. Nicholas, Colin J. Barrow, David R. Nisbet, Richard J. Williams. In vitro response to functionalized self-assembled peptide scaffolds for three-dimensional cell culture. Peptide Science, 2014, 102, 197-205.

29. Alexandra L. Rodriguez, Ting Y. Wang, Kiara F. Bruggeman, Conor Horgan, Rui Li, Richard J. Williams, Clare L. Parish, David R. Nisbet. In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair. Journal of Materials Chemistry B, 2014, 2, 7771-7778.

30. Yong Zhou, Chengsheng Jia, Rui Li, Xiaoming Zhang, Wensen He, Jingjing Li, Biao Feng, Qiuyu Xia. An efficient and expeditious synthesis European Journal of Lipid Science and Technology of phytostanyl esters in a solvent-free system. European Journal of Lipid Science and Technology, 2012, 114(8), 896-904.

31. Rui Li, Chengsheng Jia, Lin Yue, Xiaoming Zhang, Qiuyu Xia, Songlin Zhao, Biao Feng, Fang Zhong, Weijun Chen. Lipase-catalyzed synthesis of conjugated linoleyl β-sitosterol and its cholesterol-lowering properties in mice. Journal of Agricultural and Food Chemistry, 2010, 58 (3), 1898–1902.

专利

1. 李瑞,李枚秋,夏秋瑜,赵松林,马子龙,陈华. 木瓜浆处理椰乳汁制备椰子油的方法,ZL 200710305983.X,授权日,2011-11-30

2. 夏秋瑜,李瑞,李枚秋,赵松林,马子龙,陈华,陈飞. 从椰麸中提取椰子油的方法,ZL 200710184890.6,授权日,2010-1-13

3. 夏秋瑜,李瑞,赵松林,陈良秋,陈华,陈卫军,郑亚军. 一种椰子吸器果脯的制备方法,ZL 200810109712.1,授权日,2010-9-22

4. 夏秋瑜宋晨也王挥,王媛媛,宋菲李瑞赵松林. 一种营养强化型椰子油的制备方法(专利申请号:CN201911303751.X,申请日:2019-12-17

专著

1. Self-assembled peptide nanostructures for the fabrication of cell scaffolds. In: Micro and nanofabrication using self-assembled biological nanostructures. 2014, 33-61. 第三章节主编。

2. 《热带作物产品加工与技术》,科学出版社,2012,参与《椰子》章节编写。

3. 《槟榔》,中国农业出版社,2011,副主编。

4. 《椰子综合加工技术》,中国农业出版社,2007,副主编。


获奖

1. 钟赛意、陈康健、刘寿春、刘唤明、黄日明、陈建平、李瑞、刘晓菲、贾学静、于鸽. 低值鱼鳔高值化利用关键技术研发及应用,2021年中国商业联合会科学技术奖三等奖。

2. 赵松林,夏秋瑜,李瑞,陈卫军,徐兵强,李枚秋等. 天然椰子油湿法加工工艺改进及产品研发,2011年鉴定为国际先进水平。2012年获中国粮油学会科学技术奖三等奖, 中国热带农业科学院科学技术奖二等奖。

3. 陈华,赵松林,张木炎,李新菊,夏秋瑜,陈卫军,李瑞. 椰子花序汁液的采集与利用研究,2009年海南省科技进步三等奖。


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