科学研究 |
代表性科研项目(5项) [1] 国家自然科学基金面上项目:基于分子互作的牡蛎肽与花色苷DPP-IV抑制活性协同增效机制研究,2023-2025,国家自然科学基金委员会。 [2] 广东省基础与应用基础研究基金项目:基于支链氨基酸BCAAs的序列结构及代谢解析牡蛎活性肽的降血糖作用机制,2021-2024,广东省科技厅。 [3] 广东省基础与应用基础研究基金项目:基于稳态吸收和DPP-IV/GLP-1/Insulin通路解析牡蛎肽协同花色苷的降血糖增效机制,2024-2026,广东省科技厅。 [4] 湛江市海洋青年人才创新项目:牡蛎壳纳米碳酸钙递送系统对活性肽的稳定化保护作用机制研究,2021-2024,湛江市科学技术局。 [5] 湛江市科技计划项目:CMCs/CMC纳米复合水凝胶稳态保护牡蛎降糖肽作用及其吸收增效机制,2023-2025,湛江市科学技术局。 代表性论文(5篇) [1] Zhang Pei, Chen Zhongqin *(通讯作者), Zhou Longjian, Gao Jialong, Zheng Huina, Lin Haisheng, Zhu Guoping, Qin Xiaoming, Cao Wenhong*(通讯作者). Carboxymethyl cellulose and carboxymethyl chitosan-based composite nanogel as a stable delivery vehicle for oyster peptides: Characterization, absorption and transport mechanism. Food Chemistry, 2024, 442: 138464. [2] Du Ran, Li Wan, Li Jiawei, Zeng Shan, Chen Zhongqin *(通讯作者), Gao Jialong, Zheng Huina, Lin Haisheng, Zhu Guoping, Qin Xiaoming, Cao Wenhong*(通讯作者). Dynamic changes of zinc chemical speciation and zinc-containing peptides release in oysters (Crassostrea hongkongensis) during enzymatic hydrolysis. Food Bioscience, 2024, 58: 103649. [3] Chen Zhongqin, Zhu Yahui, Cao Wenhong* (通讯作者), Zhou Longjian, Zhang Chaohua, Qin Xiaoming, Zheng Huina, Lin Haisheng, Gao Jialong. Novel insight into the role of processing stages in nutritional components changes and characteristic flavors formation of noble scallop Chlamys nobilis adductors. Food Chemistry, 2022, 378: 132049. [4] Chen Zhongqin, Han Rong, Zhou Longjian, Lin Haisheng, Cao Wenhong* (通讯作者), Gao Jialong, Zheng Huina, Zhang Chaohua, Qin Xiaoming. Isolation, physicochemical and structural characterisation of a novel natural zinc polysaccharide from Crassostrea hongkongensis. International Journal of Food Science and Technology 2022, 57: 7872-7884. [5] Chen Zhongqin, Chen Yue , Xue Zihan, Gao Xudong, Jia Yanan, Wang Yajie, Lu Yangpeng, Zhang Jianying,Zhang Min, Chen Haixia* (通讯作者). Insight into the inactivation mechanism of soybean Bowman-Birk trypsin inhibitor (BBTI) induced by epigallocatechin gallate and epigallocatechin: Fluorescence, thermodynamics and docking studies. Food Chemistry, 2020, 303: 125380. 代表性授权专利 [1] 陈忠琴, 秦小明, 曹文红, 周龙建, 蒋美龄, 高加龙, 林海生, 郑惠娜. 一种具有降血糖协同增效作用的组合物及其应用, ZL 202211241470.8, 2023-08-08. [2] 陈忠琴, 曹文红, 周龙建, 张佩, 苏小洁. 牡蛎活性肽在制备抗糖尿病的药物中的应用,ZL 202311089388.2, 2024-04-19. [3] 陈忠琴, 王华, 曹文红, 周龙建, 谭明堂, 高加龙, 林海生, 秦小明. 一种富含支链氨基酸的牡蛎DPP-Ⅳ抑制肽及其制备方法和应用,ZL 202311516908.3, 2024-05-07. |