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梁远维 |
博士 讲师 硕士生导师 |
研究方向:药物设计与细胞通讯、海洋资源化学。 |
电子邮件(E-mail):liangyw@ gdou.edu.cn |
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简历
2018/06至今,广东海洋大学,化学与环境学院,讲师;
2015/09 – 2018/06,暨南大学,再生医学博士;
2016/12 – 2017/04,新加坡南洋理工大学,再生医学博士;
2012/09 – 2015/06,暨南大学,研究助理;
2009/09 – 2012/06,暨南大学,有机化学硕士;
2005/09 – 2009/06,广东海洋大学,制药工程本科。
研究内容
1. 从事药物化学、化学生物学、材料科学等交叉领域在疾病(例如:肿瘤)诊断及治疗方面的研究。主要涉及肿瘤等疾病早期诊断探针的设计,小分子药物的合成和靶向控释,及其在细胞和动物体内水平探索各种相关疾病作用的分子机制。
2. 海洋资源化学。海洋医用材料与小分子药物、新材料交叉融合的药物设计新理念在疾病治疗与诊断领域的应用。
主要承担项目
1. 广东省基础与应用基础研究基金委员会,区域联合基金-青年基金项目,2019A1515110313,双前药自组装靶向纳米粒的构建及其对卵巢癌细胞的杀伤机制研究,2020-01至2022-12,10万元,主持。
2. 湛江市科学技术局, 医药应用和疾病防治技术研究专题, 21773999, 双前药共组两亲性壳聚糖纳米粒靶向递药系统的构建及其对胃癌细胞的杀伤机制研究, 2019-11至2021-10, 5万元, 主持。
3. 湛江市科学技术局,医药应用和疾病防治技术研究专题,2021A05045,钌(II)配合物-鬼臼毒素共组水溶性前药的合成及其对肝癌的成像与治疗研究,2021-10至2023-9,5万元,主持。
4. 广东海洋大学,科研启动项目,R19057,靶向性喜树碱前药壳聚糖纳米球设计与应用,2019-10至2023-9,20万,主持。
5. 企业横向合作项目,B21095,含氮芥的钌配合物的合成及其抗肿瘤活性评价,2020-5至2025-12,8.2万,主持。
代表性论文
1. Yuanwei Liang, Naifu Zhou, Guojian Ma, Linzi Wen, Xing Wu*, Pengju Feng*. Tunable alkoxy-nucleophilic addition under photochemical condition: Dioxidation of gem‑difluoroalkenes with O2. Molecular Catalysis. 2022, 523, 112373.
2. Yuanwei Liang, Wenhua Qiu, Shixiao Li, Luxin He, Daini Wang, Xiaoxuan Gong, Kaiji Zheng, Zhen Li, and Jianping Chen*. Synthesis and In vitro Antiproliferative Activity of 5-Halogen-6-nitrobenzo[c][1,2,5]selenadiazoles on A549 Cells. Russian Journal of Bioorganic Chemistry. 2022, 48, S178–S185.
3. Yuanwei Liang*, Maojun Liang, Cuiyu Li, Daini Wang, Xiaoxuan Gong, Kaiji Zheng. Synthesis of nitrogen mustard‑based fluorophores for cell imaging and cytotoxicity studies. Journal of Advanced Pharmaceutical Technology & Research. 2023, 14, 6-11.
4. Yuanwei Liang, Chengpeng Li, Wenhua Qiu, Puwang Li, Ziming Yang, Haisheng Lin*, Yuntao Zhao*. Nitrogen Mustard Based 2-Benzylidene-1-tetralone as ICT-Based Fluorescent Probe for Drug Release Monitoring and Cervical Cancer Therapy. Russian Journal of General Chemistry. 2022, 92. 2544–2552.
5. Yuanwei Liang*, Weiting Huang, Siqi Wang, Weiming Su*, Qianyi Situ and Luxin He. Synthesis of a novel nitrogen mustard–conjugated bis-terpyridine ruthenium(II) complex as a potent anticancer agent that induces cell cycle arrest and apoptosis. Journal of Chemical Research. 2022, 42, 1–7.
6. Yuanwei Liang, Weiting Huang, Qianyi Situ, Weiming Su, Wenhua Qiu, Shixiao Li, Luxin He, and Jianping Chen*. Novel Terpyridine Conjugated Nitrogen Mustard Derivatives: Synthesis, Spectral Properties, and Anticancer Activity. Russian Journal of General Chemistry. 2022, 92, 725–731.
7. Jianping Chen, Jiarui Li, Tugui Fan, Saiyi Zhong, Xiaoming Qin, Rui Li, Jialong Gao, Yuanwei Liang*. Protective effects of curcumin/cyclodextrin polymer inclusion complex against hydrogen peroxide-induced LO2 cells damage. Food Science & Nutrition. 2022, 10, 1649–1656.
8. Yuanwei Liang, Delong Zeng, Yuanyuan You, Bin Ma, Xiaoling Li, Tianfeng Chen*. Designing Dihydrofolate Reductase Inhibitors as X‑ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer. ACS Medicinal Chemistry Letters. 2020, 11, 1421−1428.
9. Yuanwei Liang, Delong Zeng, Xiaoting Huang, Leung Chan, Chaoming Mei, Tianfeng Chen*. Cancer-targeted Design of Bioresponsive Prodrug with Enhanced Cellular Uptake for Precise Cancer Therapy. Drug Delivery. 2018, 25, 1350-1361.
10. 林海生,廖津,秦小明,曹文红,陈忠琴,高加龙,郑惠娜,章超桦,梁远维*,陆韵琪,杨维. 华贵栉孔扇贝闭壳肌酶解物的辅助降血糖功能活性评价.上海海洋大学学报. 2022.
发明专利
1. 梁远维,何露欣,黄伟婷,丘文桦,李世晓,郑锴基,王戴妮,龚晓璇,李真;一种6,7位二取代的2-(乙硫基)-蝶啶-4-胺衍生物及其制备方法与应用,2022-10-22,ZL202111230548.1
2. 梁远维,林子润,黄伟婷,何露欣,丘文桦,李世晓,王戴妮,龚晓璇;一种无金属参与的多环吲哚衍生物的制备方法,2022-09-09, ZL202111535670.X
3. LIANG Yuanwei, Tripyridine iron/ruthenium compound containing nitrogen mustard, synthesis method and application thereof, 2022-08-11, LU501930
4. 梁远维,黄伟婷,李世晓,丘文桦;一种5-卤素-6-硝基苯并硒二唑衍生物及其制备方法与应用,2022-05-17,ZL202110944221.4
5. 梁远维,苏伟明,李程鹏;一种含氮芥的咪唑杂环衍生物及其制备方法和应用,2022-02-01,ZL202110688690.4
6. 梁远维,苏伟明,王思琦,黄伟婷,陈建平,张凯恩;一种含氮芥的三联吡啶铁/钌配合物、合成方法与应用.2021-08-24,中国,ZL202110178589.4
7. 梁远维;一种含氮芥的三联吡啶配体及其制备方法和应用,2021-07-03,ZL202110177321.9