科学研究 |
代表性科研项目(5项) [1] 湛江市海洋青年人才创新项目:基于生物信息学和多组学数据融合策略解析丁内酯-I改善记忆和认知的作用机制,2022-2024,湛江市科学技术局。 [2] 湛江市科技专项:肌肽锌通过NOS信号通路对小胶质细胞功能的调控及其在帕金森病中的作用机制研究,2024-2026,湛江市科学技术局。 [3] 广东海洋大学科研启动费资助项目:基于网络药理学和实验验证的海洋天然产物丁内酯-I抗阿尔茨海默病的作用机制研究,2022-2026,广东海洋大学。 代表性论文(5篇) [1] Longjian Zhou, Andrew Chi-Hau Sue, Wilson Wen Bin Goh*(通讯作者). Examining the practical limits of batch effect-correction algorithms: When should you care about batch effects? Journal of Genetics and Genomics, 2019, 46 (9): 433-443. [2] Longjian Zhou, Limsoon Wong*(通讯作者), Wilson Wen Bin Goh*(通讯作者). Understanding missing proteins: a functional perspective. Drug Discovery Today, 2018, 23 (3): 644-651. [3] Chen Zhongqin, Su Xiaojie, Cao Wenhong, Tan Mingtang, Zhu Guoping, Gao Jialong, Zhou Longjian*(通讯作者). The discovery and characterization of a potent DPP-IV inhibitory peptide from oysters for the treatment of type 2 diabetes based on computational and experimental Studies. Marine Drugs, 2024, 22: 361. [4] Fangfang Ban, Longjian Zhou* (通讯作者), Zhiyou Yang, Yayue Liu, and Yi Zhang* (通讯作者). Aspergillusidone G potentiates the anti-inflammatory effects of polaprezinc in LPS-induced BV2 microglia: A bioinformatics and experimental study. Marine Drugs, 2024, 22(7): 324. [5] Yawen Wang†(一作), Longjian Zhou†(一作), Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban , Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang* (通讯作者). Mining xanthine oxidase inhibitors from an edible seaweed Pterocladiella capillacea by using in vitro bioassays, affinity ultrafiltration LC-MS/MS, metabolomics tools, and in silico prediction. Marine Drugs, 2023, 21:, 502. 代表性授权专利(5项) [1] 张翼, 千忠吉, 陈敏琪, 梁金月, 聂影影, 黎燕媚, 刘亚月, 周龙建, 冯妍, 洪鹏志, 宋采, 海洋真菌产的苯甲醛类化合物及其制备方法和抗炎用途, ZL202111321825.X, 2023-12-01. [2] 陈忠琴, 曹文红, 周龙建, 张佩, 苏小洁. 牡蛎活性肽在制备抗糖尿病的药物中的应用,ZL 202311089388.2, 2024-04-19. 代表性专著与教材(5项) [1] 周龙建副主编. 食品微生物学检验实验(第一版),郑州大学出版社,2023. |